Loss of p53 and altered miR15-a/16-1→MCL-1 pathway in CLL: insights from TCL1-Tg:p53(−/−) mouse model and primary human leukemia cells

Chronic lymphocytic leukemia (CLL) patients with deletion of chromosome 17p, where the tumor suppressor p53 gene is located, often develop more aggressive disease with poor clinical outcomes. To investigate the underlying mechanisms responsible for the highly malignant phenotype of 17p- CLL and to f...

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書誌詳細
主要な著者: Liu, Jinyun, Chen, Gang, Feng, Li, Zhang, Wan, Pelicano, Helene, Wang, Feng, Ogasawara, Marcia A, Lu, Weiqin, Amin, Hesham M., Croce, Carlo M., Keating, Michael J., Huang, Peng
フォーマット: Artigo
言語:Inglês
出版事項: 2013
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3806892/
https://ncbi.nlm.nih.gov/pubmed/23608884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2013.125
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