Loss of p53 and altered miR15-a/16-1→MCL-1 pathway in CLL: insights from TCL1-Tg:p53(−/−) mouse model and primary human leukemia cells

Chronic lymphocytic leukemia (CLL) patients with deletion of chromosome 17p, where the tumor suppressor p53 gene is located, often develop more aggressive disease with poor clinical outcomes. To investigate the underlying mechanisms responsible for the highly malignant phenotype of 17p- CLL and to f...

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Detalhes bibliográficos
Main Authors: Liu, Jinyun, Chen, Gang, Feng, Li, Zhang, Wan, Pelicano, Helene, Wang, Feng, Ogasawara, Marcia A, Lu, Weiqin, Amin, Hesham M., Croce, Carlo M., Keating, Michael J., Huang, Peng
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3806892/
https://ncbi.nlm.nih.gov/pubmed/23608884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2013.125
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