Targeting p53-deficient chronic lymphocytic leukemia cells in vitro and in vivo by ROS-mediated mechanism

Chronic lymphocytic leukemia (CLL) is the most common adult leukemia in Western countries. Loss of p53 function in CLL cells due to chromosome 17p deletion or p53 mutations often leads to a more malignant disease phenotype and is associated with drug resistance and poor clinical outcome. Thus, devel...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Liu, Jinyun, Chen, Gang, Pelicano, Helene, Liao, Jianwei, Huang, Jie, Feng, Li, Keating, Michael J., Huang, Peng
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5342085/
https://ncbi.nlm.nih.gov/pubmed/27655686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12110
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