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Novel role of p53 in maintaining mitochondrial genetic stability through interaction with DNA Pol γ
Mitochondrial DNA (mtDNA) mutations and deletions are frequently observed in cancer, and contribute to altered energy metabolism, increased reactive oxygen species (ROS), and attenuated apoptotic response to anticancer agents. The mechanisms by which cells maintain mitochondrial genomic integrity an...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1276176/ https://ncbi.nlm.nih.gov/pubmed/16163384 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600819 |
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