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Reduced IL-2 expression in NOD mice leads to a temporal increase in CD62L(LO)FoxP3(+)CD4(+) T cells with limited suppressor activity
IL-2 plays a critical role in the induction and maintenance of FoxP3-expressing regulatory T cells (FoxP3(+)Treg). Reduced expression of IL-2 is linked to T cell-mediated autoimmune diseases such as Type 1 diabetes (T1D), in which an imbalance between FoxP3(+)Treg and pathogenic T effectors exists....
Tallennettuna:
| Päätekijät: | , , , , , , |
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| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2011
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3805504/ https://ncbi.nlm.nih.gov/pubmed/21469091 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201040890 |
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