β-Cell–Specific IL-2 Therapy Increases Islet Foxp3(+)Treg and Suppresses Type 1 Diabetes in NOD Mice

Interleukin-2 (IL-2) is a critical cytokine for the homeostasis and function of forkhead box p3–expressing regulatory T cells (Foxp3(+)Tregs). Dysregulation of the IL-2–IL-2 receptor axis is associated with aberrant Foxp3(+)Tregs and T cell–mediated autoimmune diseases such as type 1 diabetes. Treat...

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Main Authors: Johnson, Mark C., Garland, Alaina L., Nicolson, Sarah C., Li, Chengwen, Samulski, R. Jude, Wang, Bo, Tisch, Roland
Formato: Artigo
Idioma:Inglês
Publicado: American Diabetes Association 2013
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Original Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3806588/
https://ncbi.nlm.nih.gov/pubmed/23884888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db13-0669
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