Myeloid-derived suppressor cells from tumor-bearing mice impair TGF-β-induced differentiation of CD4(+)CD25(+)FoxP3(+) Tregs from CD4(+)CD25(−)FoxP3(−) T cells

MDSCs and Tregs play an essential role in the immunosuppressive networks that contribute to tumor-immune evasion. The mechanisms by which tumors promote the expansion and/or function of these suppressive cells and the cross-talk between MDSC and Treg remain incompletely defined. Previous reports hav...

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Autors principals: Centuori, Sara M., Trad, Malika, LaCasse, Collin J., Alizadeh, Darya, Larmonier, Claire B., Hanke, Neale T., Kartchner, Jessica, Janikashvili, Nona, Bonnotte, Bernard, Larmonier, Nicolas, Katsanis, Emmanuel
Format: Artigo
Idioma:Inglês
Publicat: Society for Leukocyte Biology 2012
Matèries:
Cell Development, Differentiation, & Trafficking
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3476240/
https://ncbi.nlm.nih.gov/pubmed/22891289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.0911465
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