PIAS1 and STAT-3 impair the tumoricidal potential of IFN-γ-stimulated mouse dendritic cells generated with IL-15

Primarily defined by their antigen-presenting property, dendritic cells (DCs) are being implemented as cancer vaccines in immunotherapeutic interventions. DCs can also function as direct tumor cell killers. How DC cytotoxic activity can be efficiently harnessed and the mechanisms controlling this no...

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Hauptverfasser: Hanke, Neale T., LaCasse, Collin J., Larmonier, Claire B., Alizadeh, Darya, Trad, Malika, Janikashvili, Nona, Bonnotte, Bernard, Katsanis, Emmanuel, Larmonier, Nicolas
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4141036/
https://ncbi.nlm.nih.gov/pubmed/24777831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201343803
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