Induced Pluripotent Stem Cells from Patients with Huntington’s Disease Show CAG Repeat Expansion Associated Phenotypes

Huntington's disease (HD) is an inherited neurodegenerative disorder caused by an expanded stretch of CAG trinucleotide repeats that results in neuronal dysfunction and death. Here, the HD consortium reports the generation and characterization of 14 induced pluripotent stem cell (iPSC) lines fr...

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Detalhes bibliográficos
Main Authors: Mattis, Virginia B, Svendsen, Soshana P, Ebert, Allison, Svendsen, Clive N, King, Alvin R, Casale, Malcolm, Winokur, Sara T, Batugedara, Gayani, Vawter, Marquis, Donovan, Peter J, Lock, Leslie F, Thompson, Leslie M, Zhu, Yu, Fossale, Elisa, Singh Atwal, Ranjit, Gillis, Tammy, Mysore, Jayalakshmi, Li, Jian-hong, Seong, IhnSik, Shen, Yiping, Chen, Xiaoli, Wheeler, Vanessa C, MacDonald, Marcy E, Gusella, James F, Akimov, Sergey, Arbez, Nicolas, Juopperi, Tarja, Ratovitski, Tamara, Chiang, Jason H, Kim, Woon Roung, Chighladze, Eka, Watkin, Erin, Zhong, Chun, Makri, Georgia, Cole, Robert N, Margolis, Russell L, Song, Hongjun, Ming, Guoli, Ross, Christopher A, Kaye, Julia A, Daub, Aaron, Sharma, Punita, Mason, Amanda R, Finkbeiner, Steven, Yu, Junying, Thomson, James A, Rushton, David, Brazier, Stephen P, Battersby, Alysia A, Redfern, Amanda, Tseng, Hsui-Er, Harrison, Alexander W, Kemp, Paul J, Allen, Nicholas D, Onorati, Marco, Castiglioni, Valentina, Cattaneo, Elena, Arjomand, Jamshid
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3804072/
https://ncbi.nlm.nih.gov/pubmed/22748968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2012.04.027
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