STAT3 Regulates Proliferation and Survival of CD8(+) T Cells: Enhances Effector Responses to HSV-1 Infection, and Inhibits IL-10(+) Regulatory CD8(+) T Cells in Autoimmune Uveitis

STAT3 regulates CD4(+) T cell survival and differentiation. However, its effects on CD8(+) T cells are not well understood. Here, we show that in comparison to WT CD8(+) T cells, STAT3-deficient CD8(+) T cells exhibit a preactivated memory-like phenotype, produce more IL-2, proliferate faster, and a...

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Hauptverfasser: Yu, Cheng-Rong, Dambuza, Ivy M., Lee, Yong-Jun, Frank, Gregory M., Egwuagu, Charles E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Hindawi Publishing Corporation 2013
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3800609/
https://ncbi.nlm.nih.gov/pubmed/24204098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/359674
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