IL-12p35 induces expansion of IL-10 and IL-35-expressing regulatory B cells and ameliorates autoimmune disease

Interleukin 35 (IL-35) is a heterodimeric cytokine composed of IL-12p35 and Ebi3 subunits. IL-35 suppresses autoimmune diseases while preventing host defense to infection and promoting tumor growth and metastasis by converting resting B and T cells into IL-10-producing and IL-35-producing regulatory...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Dambuza, Ivy M., He, Chang, Choi, Jin Kyeong, Yu, Cheng-Rong, Wang, Renxi, Mattapallil, Mary J., Wingfield, Paul T., Caspi, Rachel R., Egwuagu, Charles E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5620058/
https://ncbi.nlm.nih.gov/pubmed/28959012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00838-4
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