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Dual-function of the IRF8 Transcription Factor in Autoimmune Uveitis: Loss of IRF8 in T Cells Exacerbates Uveitis while Irf8 Deletion in the Retina Confers Protection
Interferon regulatory factor 8 (IRF8) is constitutively expressed in monocytes and B cells and plays critical role in the functional maturation of microglia cells. It is induced in T-cells following antigen stimulation but its functions are less well understood. However, recent studies in mice with...
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| Опубликовано в: : | J Immunol |
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| Главные авторы: | , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2015
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4530071/ https://ncbi.nlm.nih.gov/pubmed/26163590 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1500653 |
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