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Dual-function of the IRF8 Transcription Factor in Autoimmune Uveitis: Loss of IRF8 in T Cells Exacerbates Uveitis while Irf8 Deletion in the Retina Confers Protection

Interferon regulatory factor 8 (IRF8) is constitutively expressed in monocytes and B cells and plays critical role in the functional maturation of microglia cells. It is induced in T-cells following antigen stimulation but its functions are less well understood. However, recent studies in mice with...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:J Immunol
Main Authors: Kim, Sung-Hye, Burton, Jenna, Yu, Cheng-Rong, Sun, Lin, He, Chang, Wang, Hongsheng, Morse, Herbert C., Egwuagu, Charles E.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2015
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4530071/
https://ncbi.nlm.nih.gov/pubmed/26163590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1500653
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