The integrated landscape of driver genomic alterations in glioblastoma

Glioblastoma remains one of the most challenging forms of cancer to treat. Here, we develop a computational platform that integrates the analysis of copy number variations and somatic mutations and unravels the landscape of in-frame gene fusions in glioblastoma. We find mutations with loss of hetero...

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Hlavní autoři: Frattini, Veronique, Trifonov, Vladimir, Chan, Joseph Minhow, Castano, Angelica, Lia, Marie, Abate, Francesco, Keir, Stephen T., Ji, Alan X., Zoppoli, Pietro, Niola, Francesco, Danussi, Carla, Dolgalev, Igor, Porrati, Paola, Pellegatta, Serena, Heguy, Adriana, Gupta, Gaurav, Pisapia, David J., Canoll, Peter, Bruce, Jeffrey N., McLendon, Roger E., Yan, Hai, Aldape, Ken, Finocchiaro, Gaetano, Mikkelsen, Tom, Privé, Gilbert G., Bigner, Darell D., Lasorella, Anna, Rabadan, Raul, Iavarone, Antonio
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3799953/
https://ncbi.nlm.nih.gov/pubmed/23917401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.2734
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