Transforming Fusions of FGFR and TACC Genes in Human Glioblastoma

The brain tumor glioblastoma multiforme (GBM) is among the most lethal forms of human cancer. Here, we report that a small subset of GBMs (3.1%; 3 of 97 tumors examined) harbors oncogenic chromosomal translocations that fuse in-frame the tyrosine kinase coding domains of fibroblast growth factor rec...

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Detalhes bibliográficos
Main Authors: Singh, Devendra, Chan, Joseph Minhow, Zoppoli, Pietro, Niola, Francesco, Sullivan, Ryan, Castano, Angelica, Liu, Eric Minwei, Reichel, Jonathan, Porrati, Paola, Pellegatta, Serena, Qiu, Kunlong, Gao, Zhibo, Ceccarelli, Michele, Riccardi, Riccardo, Brat, Daniel J., Guha, Abhijit, Aldape, Ken, Golfinos, John G., Zagzag, David, Mikkelsen, Tom, Finocchiaro, Gaetano, Lasorella, Anna, Rabadan, Raul, Iavarone, Antonio
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3677224/
https://ncbi.nlm.nih.gov/pubmed/22837387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1220834
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