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High-resolution view of compound promiscuity

Compound promiscuity is defined as the ability of a small molecule to specifically interact with multiple biological targets. So-defined promiscuity is relevant for drug discovery because it provides the molecular basis of polypharmacology, which is increasingly implicated in the therapeutic efficac...

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Bibliografski detalji
Glavni autori: Hu, Ye, Bajorath, Jürgen
Format: Artigo
Jezik:Inglês
Izdano: F1000Research 2013
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3799544/
https://ncbi.nlm.nih.gov/pubmed/24358872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12688/f1000research.2-144.v2
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