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SERCA Cys(674) sulphonylation and inhibition of L-type Ca(2+) influx contribute to cardiac dysfunction in endotoxemic mice, independent of cGMP synthesis
The goal of this study was to identify the cellular mechanisms responsible for cardiac dysfunction in endotoxemic mice. We aimed to differentiate the roles of cGMP [produced by soluble guanylyl cyclase (sGC)] versus oxidative posttranslational modifications of Ca(2+) transporters. C57BL/6 mice [wild...
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| Hlavní autoři: | , , , , , , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Physiological Society
2013
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3798783/ https://ncbi.nlm.nih.gov/pubmed/23934853 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00392.2012 |
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