SERCA Cys(674) sulphonylation and inhibition of L-type Ca(2+) influx contribute to cardiac dysfunction in endotoxemic mice, independent of cGMP synthesis

The goal of this study was to identify the cellular mechanisms responsible for cardiac dysfunction in endotoxemic mice. We aimed to differentiate the roles of cGMP [produced by soluble guanylyl cyclase (sGC)] versus oxidative posttranslational modifications of Ca(2+) transporters. C57BL/6 mice [wild...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Hobai, Ion A., Buys, Emmanuel S., Morse, Justin C., Edgecomb, Jessica, Weiss, Eric H., Armoundas, Antonis A., Hou, Xiuyun, Khandelwal, Alok R., Siwik, Deborah A., Brouckaert, Peter, Cohen, Richard A., Colucci, Wilson S.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Physiological Society 2013
Gaiak:
Cardiac Excitation and Contraction
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3798783/
https://ncbi.nlm.nih.gov/pubmed/23934853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00392.2012
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