SERCA Cys(674) sulphonylation and inhibition of L-type Ca(2+) influx contribute to cardiac dysfunction in endotoxemic mice, independent of cGMP synthesis

The goal of this study was to identify the cellular mechanisms responsible for cardiac dysfunction in endotoxemic mice. We aimed to differentiate the roles of cGMP [produced by soluble guanylyl cyclase (sGC)] versus oxidative posttranslational modifications of Ca(2+) transporters. C57BL/6 mice [wild...

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Hlavní autoři: Hobai, Ion A., Buys, Emmanuel S., Morse, Justin C., Edgecomb, Jessica, Weiss, Eric H., Armoundas, Antonis A., Hou, Xiuyun, Khandelwal, Alok R., Siwik, Deborah A., Brouckaert, Peter, Cohen, Richard A., Colucci, Wilson S.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2013
Témata:
Cardiac Excitation and Contraction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3798783/
https://ncbi.nlm.nih.gov/pubmed/23934853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00392.2012
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