Inactivation of Cys(674) in SERCA2 increases BP by inducing endoplasmic reticulum stress and soluble epoxide hydrolase

BACKGROUND AND PURPOSE: The kidney is essential in regulating sodium homeostasis and BP. The irreversible oxidation of Cys(674) (C674) in the sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) is increased in the renal cortex of hypertensive mice. Whether inactivation of C674 promotes hype...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Br J Pharmacol
Hlavní autoři: Liu, Gang, Wu, Fuhua, Jiang, Xiaoli, Que, Yumei, Qin, Zhexue, Hu, Pingping, Lee, Kin Sing Stephen, Yang, Jian, Zeng, Chunyu, Hammock, Bruce D., Tong, Xiaoyong
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2020
Témata:
Research Papers
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7070168/
https://ncbi.nlm.nih.gov/pubmed/31758704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14937
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky