Inactivation of Cys(674) in SERCA2 increases BP by inducing endoplasmic reticulum stress and soluble epoxide hydrolase

BACKGROUND AND PURPOSE: The kidney is essential in regulating sodium homeostasis and BP. The irreversible oxidation of Cys(674) (C674) in the sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) is increased in the renal cortex of hypertensive mice. Whether inactivation of C674 promotes hype...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Liu, Gang, Wu, Fuhua, Jiang, Xiaoli, Que, Yumei, Qin, Zhexue, Hu, Pingping, Lee, Kin Sing Stephen, Yang, Jian, Zeng, Chunyu, Hammock, Bruce D., Tong, Xiaoyong
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7070168/
https://ncbi.nlm.nih.gov/pubmed/31758704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14937
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