AMP-activated protein kinase regulates the vacuolar H(+)-ATPase via direct phosphorylation of the A subunit (ATP6V1A) in the kidney

The vacuolar H(+)-ATPase (V-ATPase) in intercalated cells contributes to luminal acidification in the kidney collecting duct and nonvolatile acid excretion. We previously showed that the A subunit in the cytoplasmic V(1) sector of the V-ATPase (ATP6V1A) is phosphorylated by the metabolic sensor AMP-...

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Autors principals: Alzamora, Rodrigo, Al-Bataineh, Mohammad M., Liu, Wen, Gong, Fan, Li, Hui, Thali, Ramon F., Joho-Auchli, Yolanda, Brunisholz, René A., Satlin, Lisa M., Neumann, Dietbert, Hallows, Kenneth R., Pastor-Soler, Núria M.
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3798744/
https://ncbi.nlm.nih.gov/pubmed/23863464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00303.2013
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