AMP-activated protein kinase inhibits alkaline pH- and PKA-induced apical vacuolar H(+)-ATPase accumulation in epididymal clear cells

Acidic luminal pH and low [HCO(3)(−)] maintain sperm quiescent during maturation in the epididymis. The vacuolar H(+)-ATPase (V-ATPase) in clear cells is a major contributor to epididymal luminal acidification. We have shown previously that protein kinase A (PKA), acting downstream of soluble adenyl...

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Detalhes bibliográficos
Main Authors: Hallows, Kenneth R., Alzamora, Rodrigo, Li, Hui, Gong, Fan, Smolak, Christy, Neumann, Dietbert, Pastor-Soler, Núria M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2009
Assuntos:
Membrane Transporters, Ion Channels, and Pumps
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2670645/
https://ncbi.nlm.nih.gov/pubmed/19211918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00004.2009
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