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Tissue-Specific Transcriptional Regulation has Diverged Significantly between Human and Mouse

We demonstrate that the binding sites for highly conserved transcription factors vary extensively between human and mouse. We mapped the binding of four tissue-specific transcription factors (FOXA2, HNF1A, HNF4A, HNF6) to 4,000 orthologous gene pairs in hepatocytes purified from human and mouse live...

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Bibliographische Detailangaben
Hauptverfasser: Odom, Duncan T., Dowell, Robin D., Jacobsen, Elizabeth S., Gordon, William, Danford, Timothy W., MacIsaac, Kenzie D., Rolfe, P. Alexander, Conboy, Caitlin M., Gifford, David K., Fraenkel, Ernest
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2007
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3797512/
https://ncbi.nlm.nih.gov/pubmed/17529977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng2047
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