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Probing the Selectivity and Protein•Protein Interactions of a Non-Reducing Fungal Polyketide Synthase Using Mechanism-Based Crosslinkers

Protein•protein interactions, which often involve interactions between an acyl carrier protein (ACP) and its partner enzymes, are important for coordinating polyketide biosynthesis. However, the nature of such interactions is not well understood, especially in the fungal non-reducing polyketide synt...

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Detalhes bibliográficos
Main Authors: Bruegger, Joel, Haushalter, Bob, Vagstad, Anna, Shakya, Gaurav, Mih, Nathan, Townsend, Craig A., Burkart, Michael D., Tsai, Shiou-Chuan
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3796367/
https://ncbi.nlm.nih.gov/pubmed/23993461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2013.07.012
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