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Probing the Selectivity and Protein•Protein Interactions of a Non-Reducing Fungal Polyketide Synthase Using Mechanism-Based Crosslinkers

Protein•protein interactions, which often involve interactions between an acyl carrier protein (ACP) and its partner enzymes, are important for coordinating polyketide biosynthesis. However, the nature of such interactions is not well understood, especially in the fungal non-reducing polyketide synt...

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Détails bibliographiques
Auteurs principaux: Bruegger, Joel, Haushalter, Bob, Vagstad, Anna, Shakya, Gaurav, Mih, Nathan, Townsend, Craig A., Burkart, Michael D., Tsai, Shiou-Chuan
Format: Artigo
Langue:Inglês
Publié: 2013
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3796367/
https://ncbi.nlm.nih.gov/pubmed/23993461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2013.07.012
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