Probing the Selectivity and Protein•Protein Interactions of a Non-Reducing Fungal Polyketide Synthase Using Mechanism-Based Crosslinkers

Protein•protein interactions, which often involve interactions between an acyl carrier protein (ACP) and its partner enzymes, are important for coordinating polyketide biosynthesis. However, the nature of such interactions is not well understood, especially in the fungal non-reducing polyketide synt...

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Autors principals: Bruegger, Joel, Haushalter, Bob, Vagstad, Anna, Shakya, Gaurav, Mih, Nathan, Townsend, Craig A., Burkart, Michael D., Tsai, Shiou-Chuan
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3796367/
https://ncbi.nlm.nih.gov/pubmed/23993461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2013.07.012
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