Lack of CD47 Impairs Bone Cell Differentiation and Results in an Osteopenic Phenotype in Vivo due to Impaired Signal Regulatory Protein α (SIRPα) Signaling

Here, we investigated whether the cell surface glycoprotein CD47 was required for normal formation of osteoblasts and osteoclasts and to maintain normal bone formation activity in vitro and in vivo. In parathyroid hormone or 1α,25(OH)(2)-vitamin D3 (D3)-stimulated bone marrow cultures (BMC) from CD4...

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Detalhes bibliográficos
Principais autores: Koskinen, Cecilia, Persson, Emelie, Baldock, Paul, Stenberg, Åsa, Boström, Ingrid, Matozaki, Takashi, Oldenborg, Per-Arne, Lundberg, Pernilla
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3795235/
https://ncbi.nlm.nih.gov/pubmed/23990469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.494591
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