Myelin down-regulates myelin phagocytosis by microglia and macrophages through interactions between CD47 on myelin and SIRPα (signal regulatory protein-α) on phagocytes

BACKGROUND: Traumatic injury to axons produces breakdown of axons and myelin at the site of the lesion and then further distal to this where Wallerian degeneration develops. The rapid removal of degenerated myelin by phagocytosis is advantageous for repair since molecules in myelin impede regenerati...

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Bibliografske podrobnosti
Main Authors: Gitik, Miri, Liraz-Zaltsman, Sigal, Oldenborg, Per-Arne, Reichert, Fanny, Rotshenker, Shlomo
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2011
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3068094/
https://ncbi.nlm.nih.gov/pubmed/21401967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-8-24
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