Myelin down-regulates myelin phagocytosis by microglia and macrophages through interactions between CD47 on myelin and SIRPα (signal regulatory protein-α) on phagocytes

BACKGROUND: Traumatic injury to axons produces breakdown of axons and myelin at the site of the lesion and then further distal to this where Wallerian degeneration develops. The rapid removal of degenerated myelin by phagocytosis is advantageous for repair since molecules in myelin impede regenerati...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Gitik, Miri, Liraz-Zaltsman, Sigal, Oldenborg, Per-Arne, Reichert, Fanny, Rotshenker, Shlomo
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: BioMed Central 2011
Gaiak:
Research
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3068094/
https://ncbi.nlm.nih.gov/pubmed/21401967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-8-24
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