The Pyridoxal 5′-Phosphate (PLP)-Dependent Enzyme Serine Palmitoyltransferase (SPT): Effects of the Small Subunits and Insights from Bacterial Mimics of Human hLCB2a HSAN1 Mutations

The pyridoxal 5′-phosphate (PLP)-dependent enzyme serine palmitoyltransferase (SPT) catalyses the first step of de novo sphingolipid biosynthesis. The core human enzyme is a membrane-bound heterodimer composed of two subunits (hLCB1 and hLCB2a/b), and mutations in both hLCB1 (e.g., C133W and C133Y)...

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Detalhes bibliográficos
Main Authors: Beattie, Ashley E., Gupta, Sita D., Frankova, Lenka, Kazlauskaite, Agne, Harmon, Jeffrey M., Dunn, Teresa M., Campopiano, Dominic J.
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3794620/
https://ncbi.nlm.nih.gov/pubmed/24175284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/194371
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