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The ORMs Interact with Transmembrane Domain 1 of Lcb1 and Regulate Serine Palmitoyltransferase Oligomerization, Activity and Localization
Serine palmitoyltransferase (SPT), an endoplasmic reticulum-localized membrane enzyme composed of a catalytic LCB1/LCB2 heterodimer and a small activating subunit (Tsc3 in yeast; ssSPTs in mammals), is negatively regulated by the evolutionarily conserved family of proteins known as the ORMs. In yeas...
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| 發表在: | Biochim Biophys Acta Mol Cell Biol Lipids |
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| Main Authors: | , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2018
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6373489/ https://ncbi.nlm.nih.gov/pubmed/30529276 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbalip.2018.11.007 |
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