The ORMs Interact with Transmembrane Domain 1 of Lcb1 and Regulate Serine Palmitoyltransferase Oligomerization, Activity and Localization

Serine palmitoyltransferase (SPT), an endoplasmic reticulum-localized membrane enzyme composed of a catalytic LCB1/LCB2 heterodimer and a small activating subunit (Tsc3 in yeast; ssSPTs in mammals), is negatively regulated by the evolutionarily conserved family of proteins known as the ORMs. In yeas...

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Detalhes bibliográficos
Publicado no:Biochim Biophys Acta Mol Cell Biol Lipids
Main Authors: Han, Gongshe, Gupta, Sita D., Gable, Kenneth, Bacikova, Dagmar, Sengupta, Nivedita, Somashekarappa, Niranjanakumari, Proia, Richard L., Harmon, Jeffrey M., Dunn, Teresa M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6373489/
https://ncbi.nlm.nih.gov/pubmed/30529276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbalip.2018.11.007
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