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Expression of the ORMDLS, Modulators of Serine Palmitoyltransferase, Is Regulated by Sphingolipids in Mammalian Cells

The relationship between serine palmitoyltransferase (SPT) activity and ORMDL regulation of sphingolipid biosynthesis was investigated in mammalian HEK293 cells. Each of the three human ORMDLs reduced the increase in long-chain base synthesis seen after overexpression of wild-type SPT or SPT contain...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Gupta, Sita D., Gable, Kenneth, Alexaki, Aikaterini, Chandris, Panagiotis, Proia, Richard L., Dunn, Teresa M., Harmon, Jeffrey M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2015
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4281770/
https://ncbi.nlm.nih.gov/pubmed/25395622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.588236
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