SIRT6 exhibits nucleosome-dependent deacetylase activity

The SIRT6 deacetylase is a key regulator of mammalian genome stability, metabolism and lifespan. Previous studies indicated that SIRT6 exhibits poor deacetylase activity in vitro. Here, we explored the specific conditions that allow SIRT6 to function as a significant deacetylase. We show that SIRT6...

Full description

Saved in:
Bibliographic Details
Main Authors: Gil, Reuven, Barth, Shaul, Kanfi, Yariv, Cohen, Haim Y.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2013
Subjects:
Gene Regulation, Chromatin and Epigenetics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3794599/
https://ncbi.nlm.nih.gov/pubmed/23892288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt642
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items