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SIRT6 exhibits nucleosome-dependent deacetylase activity
The SIRT6 deacetylase is a key regulator of mammalian genome stability, metabolism and lifespan. Previous studies indicated that SIRT6 exhibits poor deacetylase activity in vitro. Here, we explored the specific conditions that allow SIRT6 to function as a significant deacetylase. We show that SIRT6...
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| Huvudupphovsmän: | , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
Oxford University Press
2013
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3794599/ https://ncbi.nlm.nih.gov/pubmed/23892288 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt642 |
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