Characterization of physiological defects in adult SIRT6(-/-) mice

The NAD+-dependent SIRT6 deacetylase was shown to be a major regulator of lifespan and healthspan. Mice deficient for SIRT6 develop a premature aging phenotype and metabolic defects, and die before four weeks of age. Thus, the effect of SIRT6 deficiency in adult mice is unknown. Here we show that SI...

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發表在:PLoS One
Main Authors: Peshti, Victoria, Obolensky, Alexey, Nahum, Liat, Kanfi, Yariv, Rathaus, Moran, Avraham, Maytal, Tinman, Simon, Alt, Fredrick W., Banin, Eyal, Cohen, Haim Y.
格式: Artigo
語言:Inglês
出版: Public Library of Science 2017
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5407791/
https://ncbi.nlm.nih.gov/pubmed/28448551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0176371
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