The ribosome triggers the stringent response by RelA via a highly distorted tRNA

The bacterial stringent response links nutrient starvation with the transcriptional control of genes. This process is initiated by the stringent factor RelA, which senses the presence of deacylated tRNA in the ribosome as a symptom of amino-acid starvation to synthesize the alarmone (p)ppGpp. Here w...

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Main Authors: Agirrezabala, Xabier, Fernández, Israel S, Kelley, Ann C, Cartón, David Gil, Ramakrishnan, Venki, Valle, Mikel
Format: Artigo
Sprog:Inglês
Udgivet: European Molecular Biology Organization 2013
Fag:
Scientific Reports
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3790049/
https://ncbi.nlm.nih.gov/pubmed/23877429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2013.106
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