cAMP Response Element-binding Protein (CREB) and Nuclear Factor κB Mediate the Tamoxifen-induced Up-regulation of Glutamate Transporter 1 (GLT-1) in Rat Astrocytes

Tamoxifen (TX), a selective estrogen receptor modulator, exerts antagonistic effects on breast tissue and is used to treat breast cancer. Recent evidence also suggests that it may act as an agonist in brain tissue. We reported previously that TX enhanced the expression and function of glutamate tran...

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Hlavní autoři: Karki, Pratap, Webb, Anton, Smith, Keisha, Lee, Kyuwon, Son, Deok-Soo, Aschner, Michael, Lee, Eunsook
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2013
Témata:
Gene Regulation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3789995/
https://ncbi.nlm.nih.gov/pubmed/23955341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.483826
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