Yin Yang 1 Is a Repressor of Glutamate Transporter EAAT2, and It Mediates Manganese-Induced Decrease of EAAT2 Expression in Astrocytes

Impairment of astrocytic glutamate transporter (GLT-1; EAAT2) function is associated with multiple neurodegenerative diseases, including Parkinson's disease (PD) and manganism, the latter being induced by chronic exposure to high levels of manganese (Mn). Mn decreases EAAT2 promoter activity an...

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Huvudupphovsmän: Karki, Pratap, Webb, Anton, Smith, Keisha, Johnson, James, Lee, Kyuwon, Son, Deok-Soo, Aschner, Michael, Lee, Eunsook
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2014
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Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3993574/
https://ncbi.nlm.nih.gov/pubmed/24469401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01176-13
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