Histone Deacetylase Inhibition Promotes Osteoblast Maturation by Altering the Histone H4 Epigenome and Reduces Akt Phosphorylation

Bone has remarkable regenerative capacity, but this ability diminishes during aging. Histone deacetylase inhibitors (HDIs) promote terminal osteoblast differentiation and extracellular matrix production in culture. The epigenetic events altered by HDIs in osteoblasts may hold clues for the developme...

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Bibliografiske detaljer
Main Authors: Dudakovic, Amel, Evans, Jared M., Li, Ying, Middha, Sumit, McGee-Lawrence, Meghan E., van Wijnen, Andre J., Westendorf, Jennifer J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2013
Fag:
Gene Regulation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3789974/
https://ncbi.nlm.nih.gov/pubmed/23940046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.489732
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