Nox4 NADPH Oxidase Mediates Peroxynitrite-dependent Uncoupling of Endothelial Nitric-oxide Synthase and Fibronectin Expression in Response to Angiotensin II: ROLE OF MITOCHONDRIAL REACTIVE OXYGEN SPECIES

Activation of glomerular mesangial cells (MCs) by angiotensin II (Ang II) leads to extracellular matrix accumulation. Here, we demonstrate that, in MCs, Ang II induces endothelial nitric-oxide synthase (eNOS) uncoupling with enhanced generation of reactive oxygen species (ROS) and decreased producti...

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Bibliografski detalji
Glavni autori: Lee, Doug-Yoon, Wauquier, Fabien, Eid, Assaad A., Roman, Linda J., Ghosh-Choudhury, Goutam, Khazim, Khaled, Block, Karen, Gorin, Yves
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2013
Teme:
Signal Transduction
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3789965/
https://ncbi.nlm.nih.gov/pubmed/23940049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.470971
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