The NADPH Oxidase Subunit p22(phox) Inhibits the Function of the Tumor Suppressor Protein Tuberin

Mutations in the von Hippel-Lindau (VHL) gene give rise to renal cell carcinoma. Reactive oxygen species, generated by Nox oxidases, are involved in tumorigenesis. We have previously demonstrated that in VHL-deficient cells, p22(phox)-dependent Nox1 and Nox4 oxidases maintain hypoxia inducible facto...

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Detalhes bibliográficos
Main Authors: Block, Karen, Gorin, Yves, New, David D., Eid, Assaad, Chelmicki, Tomasz, Reed, Amanda, Choudhury, Goutam Ghosh, Parekh, Dipen J., Abboud, Hanna E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2010
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2861109/
https://ncbi.nlm.nih.gov/pubmed/20304964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.090606
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