Nox4 NADPH Oxidase Mediates Peroxynitrite-dependent Uncoupling of Endothelial Nitric-oxide Synthase and Fibronectin Expression in Response to Angiotensin II: ROLE OF MITOCHONDRIAL REACTIVE OXYGEN SPECIES

Activation of glomerular mesangial cells (MCs) by angiotensin II (Ang II) leads to extracellular matrix accumulation. Here, we demonstrate that, in MCs, Ang II induces endothelial nitric-oxide synthase (eNOS) uncoupling with enhanced generation of reactive oxygen species (ROS) and decreased producti...

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Detalhes bibliográficos
Main Authors: Lee, Doug-Yoon, Wauquier, Fabien, Eid, Assaad A., Roman, Linda J., Ghosh-Choudhury, Goutam, Khazim, Khaled, Block, Karen, Gorin, Yves
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3789965/
https://ncbi.nlm.nih.gov/pubmed/23940049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.470971
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