Nox4 NADPH Oxidase Mediates Peroxynitrite-dependent Uncoupling of Endothelial Nitric-oxide Synthase and Fibronectin Expression in Response to Angiotensin II: ROLE OF MITOCHONDRIAL REACTIVE OXYGEN SPECIES

Activation of glomerular mesangial cells (MCs) by angiotensin II (Ang II) leads to extracellular matrix accumulation. Here, we demonstrate that, in MCs, Ang II induces endothelial nitric-oxide synthase (eNOS) uncoupling with enhanced generation of reactive oxygen species (ROS) and decreased producti...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Lee, Doug-Yoon, Wauquier, Fabien, Eid, Assaad A., Roman, Linda J., Ghosh-Choudhury, Goutam, Khazim, Khaled, Block, Karen, Gorin, Yves
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2013
Aiheet:
Signal Transduction
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3789965/
https://ncbi.nlm.nih.gov/pubmed/23940049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.470971
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia