Nox4 NAD(P)H Oxidase Mediates Src-dependent Tyrosine Phosphorylation of PDK-1 in Response to Angiotensin II: ROLE IN MESANGIAL CELL HYPERTROPHY AND FIBRONECTIN EXPRESSION

Activation of glomerular mesangial cells (MCs) by angiotensin II (Ang II) leads to hypertrophy and extracellular matrix accumulation. Here, we demonstrate that, in MCs, Ang II induces an increase in PDK-1 (3-phosphoinositide-dependent protein kinase-1) kinase activity that required its phosphorylati...

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Bibliografiska uppgifter
Huvudupphovsmän: Block, Karen, Eid, Assaad, Griendling, Kathy K., Lee, Duck-Yoon, Wittrant, Yohann, Gorin, Yves
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2008
Ämnen:
Mechanisms of Signal Transduction
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2527116/
https://ncbi.nlm.nih.gov/pubmed/18559349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M803964200
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