IGF-I increases the expression of fibronectin by Nox4-dependent Akt phosphorylation in renal tubular epithelial cells

Extracellular matrix accumulation contributes to the progression of chronic kidney disease. Many growth factors including insulin-like growth factor-I (IGF-I) enhance matrix protein accumulation. Proximal tubular epithelial cells (PTCs) synthesize matrix proteins. NADPH oxidases are major sources of...

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Hlavní autoři: New, David D., Block, Karen, Bhandhari, Basant, Gorin, Yves, Abboud, Hanna E.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2012
Témata:
Receptors and Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3328902/
https://ncbi.nlm.nih.gov/pubmed/21940672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00141.2011
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