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Mechanisms of Podocyte Injury in Diabetes: Role of Cytochrome P450 and NADPH Oxidases

OBJECTIVE: We investigated the role of cytochrome P450 of the 4A family (CYP4A), its metabolites, and NADPH oxidases both in reactive oxygen species (ROS) production and apoptosis of podocytes exposed to high glucose and in OVE26 mice, a model of type 1 diabetes. RESEARCH DESIGN AND METHODS: Apoptos...

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Detalhes bibliográficos
Main Authors: Eid, Assaad A., Gorin, Yves, Fagg, Bridget M., Maalouf, Rita, Barnes, Jeffrey L., Block, Karen, Abboud, Hanna E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2671039/
https://ncbi.nlm.nih.gov/pubmed/19208908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db08-1536
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