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Mammalian Target of Rapamycin Regulates Nox4-Mediated Podocyte Depletion in Diabetic Renal Injury

Podocyte apoptosis is a critical mechanism for excessive loss of urinary albumin that eventuates in kidney fibrosis. Pharmacological doses of the mammalian target of rapamycin (mTOR) inhibitor rapamycin reduce albuminuria in diabetes. We explored the hypothesis that mTOR mediates podocyte injury in...

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書誌詳細
主要な著者: Eid, Assaad A., Ford, Bridget M., Bhandary, Basant, de Cassia Cavaglieri, Rita, Block, Karen, Barnes, Jeffrey L., Gorin, Yves, Choudhury, Goutam Ghosh, Abboud, Hanna E.
フォーマット: Artigo
言語:Inglês
出版事項: American Diabetes Association 2013
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3717863/
https://ncbi.nlm.nih.gov/pubmed/23557706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db12-1504
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