The Upf Factor Complex Interacts with Aberrant Products Derived from mRNAs Containing a Premature Termination Codon and Facilitates Their Proteasomal Degradation

Up-frameshift (Upf) factors eliminate aberrant mRNAs containing a specific premature termination codon (PTC). Here, we show that Upf complex facilitates the ubiquitin-dependent degradation of products derived from mRNA containing specific PTCs in Saccharomyces cerevisiae. The efficiency of recruitme...

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Main Authors: Kuroha, Kazushige, Ando, Koji, Nakagawa, Reiko, Inada, Toshifumi
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Protein Synthesis and Degradation
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3789962/
https://ncbi.nlm.nih.gov/pubmed/23928302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.460691
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