mRNAs containing NMD-competent premature termination codons are stabilized and translated under UPF1 depletion

mRNAs containing premature termination codons (PTCs) are rapidly degraded through nonsense-mediated mRNA decay (NMD). However, some PTC-containing mRNAs evade NMD, and might generate mutant proteins responsible for various diseases, including cancers. Using PTC-containing human genomic β-globin cons...

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Publicado en:Sci Rep
Main Authors: Kim, Won Kyu, Yun, SeongJu, Kwon, Yujin, You, Kwon Tae, Shin, Nara, Kim, Jiyoon, Kim, Hoguen
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5696521/
https://ncbi.nlm.nih.gov/pubmed/29158530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-16177-9
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