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ATP hydrolysis by UPF1 is required for efficient translation termination at premature stop codons
Nonsense-mediated mRNA decay (NMD) represents a eukaryotic quality control pathway that recognizes and rapidly degrades transcripts harbouring nonsense mutations to limit accumulation of non-functional and potentially toxic truncated polypeptides. A critical component of the NMD machinery is UPF1, a...
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| Published in: | Nat Commun |
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| Main Authors: | , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Nature Publishing Group
2016
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5196439/ https://ncbi.nlm.nih.gov/pubmed/28008922 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14021 |
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