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ATP hydrolysis by UPF1 is required for efficient translation termination at premature stop codons

Nonsense-mediated mRNA decay (NMD) represents a eukaryotic quality control pathway that recognizes and rapidly degrades transcripts harbouring nonsense mutations to limit accumulation of non-functional and potentially toxic truncated polypeptides. A critical component of the NMD machinery is UPF1, a...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Serdar, Lucas D., Whiteside, DaJuan L., Baker, Kristian E.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5196439/
https://ncbi.nlm.nih.gov/pubmed/28008922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14021
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