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mRNAs containing NMD-competent premature termination codons are stabilized and translated under UPF1 depletion
mRNAs containing premature termination codons (PTCs) are rapidly degraded through nonsense-mediated mRNA decay (NMD). However, some PTC-containing mRNAs evade NMD, and might generate mutant proteins responsible for various diseases, including cancers. Using PTC-containing human genomic β-globin cons...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5696521/ https://ncbi.nlm.nih.gov/pubmed/29158530 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-16177-9 |
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