PKR negatively regulates leukemia progression in association with PP2A activation, Bcl-2 inhibition and increased apoptosis

Reduced expression and activity of the proapoptotic, double-stranded RNA-dependent protein kinase, PKR (protein kinase R) is observed in breast, lung and various leukemias, suggesting that loss of PKR potentiates transformation. Now we report that decreased PKR activity inhibits chemotherapy-induced...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Cheng, X, Bennett, R L, Liu, X, Byrne, M, Stratford May, W
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2013
Témata:
Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3789206/
https://ncbi.nlm.nih.gov/pubmed/24013665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bcj.2013.42
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky